Modeling Multiallelic Selection Using a Moran Model

Modeling multiallelic selection using a Moran model.

We present a Moran-model approach to modeling general multiallelic selection in a finite population and show how it may be used to develop theoretical models of biological systems of balancing selection such as plant gametophytic self-incompatibility loci. We propose new expressions for the stationary distribution of allele frequencies under selection and use them to show that the continuous-ti...

The Moran model with selection

Fluctuating Selection in the Moran

Contrary to classical population genetics theory, experiments demonstrate that fluctuating selection can protect a haploid polymorphism in the absence of frequency dependent effects on fitness. Using forward simulations with the Moran model, we confirm our analytical results showing that a fluctuating selection regime, with a mean selection coefficient of zero, promotes polymorphism. We find th...

The historical Moran model

We consider a multi-type Moran model (in continuous time) with selection and typedependent mutation. This paper is concerned with the evolution of genealogical information forward in time. For this purpose we define and analytically characterize a pathvalued Markov process that contains in its state at time t the extended ancestral lines (adding genealogical distances) of the population alive a...

Repeated Adaptive Introgression at a Gene under Multiallelic Balancing Selection

Recently diverged species typically have incomplete reproductive barriers, allowing introgression of genetic material from one species into the genomic background of the other. The role of natural selection in preventing or promoting introgression remains contentious. Because of genomic co-adaptation, some chromosomal fragments are expected to be selected against in the new background and resis...